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Título

THE RELATIONSHIP BETWEEN TESTOSTERONE AND BLADDER CANCER

Resumo

INTRODUCTION: Bladder cancer (BC) is among the most common malignancies in the urinary
system, being the ninth most common tumor in the world. According to the Global Cancer
Observatory (GCO), 573.278 individuals were diagnosed with BC in 2020. Furthermore, the
occurrence of bladder cancer is three to five times higher in men than in women, being the
second most frequent malignant neoplasm in the genitourinary tract. Therefore, due to its incidence, this body of work has the objective of exploring and comprehending whether testosterone, as it is predominant in the
bloodstream, plays a role in BC. As urinary tract infections are more common in women,
misinterpretation of the irritative symptoms of bladder cancer, such as hematuria, urinary
frequency or dysuria, can result in a late diagnosis, leading to the discovery of the carcinoma at
a more advanced stage. This study also aims to understand the relationship between testosterone
and the increase in the diagnosis of bladder cancer. METHODS: In this article, the literature
review method was used, with the purpose of synthesizing research results on the topic in
question, contributing to the deepening of knowledge about it. A search for scientific articles
was carried out on PubMed and ScienceDirect. For such, the following descriptors were utilized:
“Testosterone” and “Bladder Cancer”. RESULTS: Over the past few decades, there has been an
increasing in the global incidence of bladder cancer. Through studies, it was discovered that
testosterone is an independent factor in bladder cancer. Previous research has found that the
incidence of BC is directly related to the androgen receptor and testosterone. Therefore,
androgen deprivation has shown an effect on the recurrence of BC. Androgen suppression
therapy is associated with a lower risk of recurrence. CONCLUSION: In this research, the
analogy between testosterone levels and the high number of cases of bladder cancer was
demonstrated.