Dados do Trabalho

Título

A CASE-CONTROL STUDY TO EVALUATE THE RISK FACTORS OF PEYRONIE´S DISEASE

Introdução e Objetivo

Background: Peyronie's disease (PD) is a benign pathology that develops fibrous plaques within the tunica albuginea of the penis, causing penile tortuosity, shortening in length, painful erections and erectile dysfunction. Although the disease was described more than 250 years ago, the precise etiology remains obscure. Aim: To demonstrate the clinical and epidemiological profile of patients with PD as well as to evaluate the main predisposing risk factors related to the disease.

Método

A case-control study was conducted with 156 consecutive PD patients and 254 age-matched controls. Men were interviewed regarding demographic and lifestyle characteristics, co-morbidities and current medication use. International Index of Erectile Function was used to assess the presence and severity of erectile dysfunction. Anthropometric and laboratory evaluations were performed. Potential risk factors for PD were analyzed using bivariate and multivariate models (P

Resultados

White skin color, no married status, abusive consumption of alcoholic beverages and clinical conditions such as hypertension, rheumatologic diseases and Dupuytren´s disease were more commonly associated with PD (P

Conclusão

White skin color, no married status, abusive consumption of alcoholic beverages, hypertension, rheumatologic diseases, Dupuytren´s disease, captopril, thiazide diuretics and ASA were associated with PD. Erectile dysfunction was associated with the presence of PD, except in younger men.